AZNPbio sample library is unique
We select species for collection according to the potential of finding new bio-actives. Each species is carefully screened to ensure it has medicinal use records and acceptable safety profile.
Once bio-materials arrive at our facility, sorting, checking, processing, cataloging, drying and grinding are carried out in an orderly and careful manner. We use freeze-dryer for some tough-drying samples to avoid chemical degradation and molding.
Many natural product high throughput screening projects fail due to the use of single protocol to process all kinds of bio-masses. Our solution is using different protocols to treat different bio-materials.
Step-wise solvent partition, serial extraction and column separation are used to eliminate interference substances such as salts, proteins, tannin, fats, sugars, polysaccharides, chlorophylls and other commonly found chemicals in natural products, so that assay interferences will be reduced by using our samples.
We categorizes and collects the parts from one living organism separately to reduce man-made extract complexity. Our assay-ready samples from different plant parts such as leaves, roots, and barks are loaded into different master plates for easy and uniformed assay dilution.
Pharmaceutical industry's productivity continues to be dismal. One reason may have been the diminished interest in natural products drug discovery as the industry embraced promising and exciting new technologies.
However, combinatorial chemistry's promise to fill drug development pipelines with de novo synthetic small-molecule drug candidates is unfulfilled.
Natural compounds have complicted structures and exist in complex mixture. The complicated structures have an advantage in that they are extremely novel compounds, but the complication also makes isolation and identification difficult.
The mixture of thousands of different types of compounds with various contents in a living organism extract can cause bio-assay interference which often leads to bio-screening failure. High content molecules found in most natural product extracts, such as chlorophyll, fat and tannin act as interference in screening process.
The practical difficulties of natural product drug discovery are being overcome by the advances in separation and identification technologies.